A Study of Factors Contributing to Denture Stomatitis in a North Indian Community

Factors like oral and denture hygiene, presence of saliva, age of the denture, and degree of colonization with Candida albicans are to be evaluated as local contributing factors for causing denture stomatitis. 100 patients aged 30 to 70 years were selected for the study. Among these, 70 patients were labeled test group showing signs of stomatitis and 30 patients as control group as they showed no inflammatory signs. Clinical tests included oral and denture hygiene evaluation, salivary measurements, and age of the dentures, and microscopic investigations were done. Results showed no significant differences between the two groups in terms of saliva, oral and denture hygiene habits, and denture age. Test group showed stomatitis in patients who were wearing dentures for 5 to 10 years compared to control group who were wearing dentures for 10 years and above. Denture age was proportional to Candida colonization and not to degree of inflammation. Significant differences were found in Candida colonization of the fitting surface of the denture between stomatitis and control groups. Poor denture hygiene habits are the most prominent contributing factor for denture stomatitis and colonization

Role of Government in Development of Sustainable Ecotourism in Karnataka

Ecotourism is a visit to the natural reserved areas like national parks, sanctuaries and biosphere reserves for sightseeing as tourism. The visit of reserved areas by the tourists, the entrepreneurs, the government and the host community, the major agencies or stakeholders in ecotourism, has created numerous effects in the field of ecology, socio-cultural, economic which are indefensible lots of time. Sustainability is also a sober concern. The current article inspects sustainability as an association with all its stakeholders and proposes on preserving equilibrium in the correlation which is necessary to achieve sustainability. The part of rule in attaining sustainability is surveyed and found that it helps in reinstating the essential stability in the association with the stakeholders in ecotourism.  Ecotourism in Karnataka is steadily qualified for the consideration of the tourists, the government and the entrepreneurs for clear motive. Karnataka has necessary prospective in ecotourism to cope up with the interests of the tourists, the entrepreneurs and the government but does sustainability study with  concern in the schedule of these organizations. An environmental law is one of the most effectual tools for executing sustainability; it needs plenty of provisions to institute synchronization between the stakeholders and hence the goal of sustainability in ecotourism remains unachievable

Study of Emotional Effects of Tooth Loss in an Aging North Indian Community

A study was conducted to study the emotional effects of complete and partial loss of teeth in an aging North Indian community. A questionnaire was prepared for 400 elderly people above the age of 60 years, who were interviewed in dental checkup camps. The data was collected and analyzed using chi-square or chi-square exact tests. 25% of the people were found to have difficulty accepting tooth loss, whereas more than 50% of the people reported to have restricted their food choices. Other problems like reduced attendance in social gatherings for lunch/dinner or eating out in public were also noted. 56% felt that dental consultation prior to tooth loss would have helped them in a significant way. It was concluded that tooth loss did not have a marked impact on emotions of the people but affected their daily social activities, however there was negligible difference between complete and partial tooth loss subjects

AC magnetotransport, magnetocaloric and multiferroic studies in selected oxides

Ph.DDOCTOR OF PHILOSOPH

Free vibration analysis of simply supported rectangular plates

In this paper, numerical analysis for free vibration of simply supported thin rectangular plates has been simulated using Ansys. The vibration of plate follows Kirchhoff plate theory. The natural frequency calculated using Ansys has been compared with Levy type solution results available in the literature. It is observed that the natural frequencies of the simply supported rectangular plate is in close agreement with exact solution results as reported in literature

A critical review of anticancer properties of Withania somnifera (L.) Dunal with respect to the biochemical mechanisms of its phytochemical constituents

Cancer is a leading cause of mortality worldwide, the conventional chemotherapeutic drugs have been known for their toxicity and numerous side effects. A new approach to treat cancer involves phytochemical drugs. In the present review, anti-cancer activity of a class of steroidal lactones called withanolides obtained from Withania somnifera (L.) Dunal is discussed. The commonly studied bioactive compounds namely withaferin-A, withanoside IV, withanoside VI and withanolide-A among others obtained from methanolic and chloroform extract of the leaves and various alcoholic, aqueous and chloroform extract of roots have shown inhibition to various human cancer cell lines including skin, breast, colon, prostate, liver, ovary, cervical and lung. Prominent mechanisms of action include induction of apoptosis by NOS upregulation, ROS production and NBS2 or COX-2 inhibition; cytotoxicity by humoral and cell mediated immune response, activation of p53 and pRB and inhibition of various viral oncoproteins; cell cycle arrest by Cdc2 facilitated mitotic catastrophe, cyclin-D1 down-regulation and inhibition of transcription factors. Cancers are also controlled by inhibition of angiogenesis and metastasis of the tumor cells. In addition to anti-tumorogenic properties, W. somnifera also holds properties that make it a potential adjuvant in integrated cancer therapeutics and in enhancing the effectiveness of ongoing radiation therapy

In-vitro screening of cucurbitaceous plants for antidiabetic potential

209-225Natural products traditionally have played an important role in drug discovery and formed the basis of most early medicines. Medicinal plants and drugs derived from them have been explored extensively for their antidiabetic potential. Extensive literature survey revealed that the family cucurbitaceae of higher plants has contributed a lot in traditional system of medicines for developing antidiabetic formulations. The most discussed Momordica charantia and Cucumis sativus are some examples. However, many cucurbitaceous taxa are yet to be explored. The objectives of the present study are to gather data from literature on the antidiabetic potential of cucurbitaceous plants with their traditional usage and in-vitro screening of different extracts and fractions of collected cucurbitaceous plants for their antidiabetic activity in the glucose utilization assay (GUA) on L6 cell line. Based on literature survey, a list of 32 plant species of cucurbitaceae family was prepared, which have been reported for antidiabetic activity or mentioned in ethnomedicinal and traditional system of medicines for antidiabetic potential. A total of 15 crude extract and their 75 fractions were prepared from 9 collected cucurbitaceous plants and their parts and screened against differentiated rat skeletal (L6) muscle cells in glucose uptake assay. Eight extracts/fractions from 4 plants (Cucumis callosus fruit, Luffa echinata fruit, Coccinia indica fruit and Cucurbita species aerial part) were found active in antidiabetic screening. The best antidiabetic activity was found in chloroform fraction of Luffa echinata fruit. After bioactivity guided column fractionation of this active fraction, the fraction M010/S/3/5 showed maximum activity in glucose uptake assay. EC50 was calculated as 0.59 μg/mL showed potent antidiabetic compound. Present study revealed that there is huge potential in cucurbitaceous plants for developing antidiabetic drug